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Updated: May 22, 2026
06:21
Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Targeted therapy for gastric cancer
Elizabeth C Smyth1, David Cunningham
1Royal Marsden Hospital, Downs Road, Surrey, SM2 5PT, UK. elizabeth.smyth@rmh.nhs.uk
Current Treatment Options in Oncology
|May 4, 2012
Summary
Targeted therapies show promise for advanced gastric cancer, offering improved survival over chemotherapy. Molecularly defined patient subsets are key for developing effective, less toxic treatments.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Advanced gastric cancer survival is poor with standard chemotherapy (9-11 months median).
- Combination therapies improve survival but increase toxicity in compromised patients.
- Molecular phenotypes influence gastric cancer behavior and treatment response.
Purpose of the Study:
- To review emerging targeted therapies for advanced gastric cancer.
- To highlight the importance of molecular profiling for patient selection.
- To discuss the potential of novel agents and pathways.
Main Methods:
- Review of current literature on gastric cancer treatment.
- Analysis of gene expression profiling and genomic landscape data.
- Evaluation of clinical trial outcomes for targeted agents.
Main Results:
- HER2-targeted therapy (trastuzumab) improves survival in HER2+ gastric cancer.
- EGFR-targeted therapy has shown limited success in unselected patients.
- Anti-angiogenic therapy (bevacizumab) failed in a large trial, but showed regional variations.
- Novel agents targeting MET/HGF and FGFR axes are in development.
Conclusions:
- Molecularly targeted therapies offer potential for improved survival in advanced gastric cancer.
- Patient selection based on molecular profiles is crucial for future treatment success.
- Further research into novel pathways and combination strategies is warranted.
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