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Interphase

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.

Interphase

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Phases of Interphase
Following each period of mitosis and cytokinesis, eukaryotic cells enter interphase, during which they grow and replicate...

Interphase

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Phases of Interphase
Following each period of mitosis and cytokinesis, eukaryotic cells enter interphase, during which they grow and replicate...

Interphase

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.

What is the Cell Cycle?

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...

What is the Cell Cycle?

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...

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Related Experiment Video

Updated: May 22, 2026

Efficient iPS Cell Generation from Blood Using Episomes and HDAC Inhibitors

Efficient iPS Cell Generation from Blood Using Episomes and HDAC Inhibitors

Published on: October 28, 2014

The abbreviated pluripotent cell cycle.

Kristina Kapinas¹, Rodrigo Grandy, Prachi Ghule

¹Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Journal of Cellular Physiology

|May 4, 2012

Summary

This summary is machine-generated.

Human embryonic stem cells (hESCs) exhibit rapid, symmetrical cell division, driven by a unique cell cycle. Understanding this abbreviated cycle is crucial for controlling cell proliferation and differentiation in regenerative medicine applications.

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Last Updated: May 22, 2026

Efficient iPS Cell Generation from Blood Using Episomes and HDAC Inhibitors

Efficient iPS Cell Generation from Blood Using Episomes and HDAC Inhibitors

Published on: October 28, 2014

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

Area of Science:

Stem cell biology
Cell cycle regulation
Developmental biology

Background:

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) proliferate rapidly via symmetrical cell division.
Lineage-committed cells exhibit extended cell cycles, while tissue-specific stem cell self-renewal relies on asymmetric division.
Pluripotent cell cycle regulation involves temporal, regulatory, and structural contexts, with a short G1 phase being characteristic of hESCs.

Purpose of the Study:

To explore the temporal, regulatory, and structural contexts of the pluripotent cell cycle in hESCs.
To investigate the role of the naïve transcriptome in regulating the hESC cell cycle.
To examine the architectural organization of gene expression machinery in nuclear microenvironments that define pluripotency.

Main Methods:

Analysis of the temporal dynamics of the hESC cell cycle, focusing on G1, S, G2, and M phases.
Investigation of the naïve transcriptome's role in controlling hESC proliferation and lineage commitment.
Exploration of nuclear microenvironment organization and its impact on gene expression in pluripotent cells.

Main Results:

hESCs possess a short G1 phase within their cell cycle, facilitating rapid proliferation.
The naïve transcriptome of hESCs plays a critical role in regulating the cell cycle, promoting self-renewal and suppressing differentiation.
Unique architectural organization of gene regulatory machinery within nuclear microenvironments contributes to maintaining pluripotency.

Conclusions:

Understanding the abbreviated cell cycle of hESCs is key to controlling proliferation versus differentiation.
Knowledge of pluripotent cell cycle biology has significant implications for wound healing, tissue engineering, and cell-based therapies.
Further research into the rules governing hESC proliferation is needed for comprehensive understanding and clinical application.