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Use of a cell hybrid test system to demonstrate that benomyl induces aneuploidy and polyploidy
P A Zelesco1, I Barbieri, J A Graves
1Department of Genetics and Human Variation, La Trobe University, Bundoora, Australia.
Mutation Research
|December 1, 1990
Abstract:
We have monitored the segregation of a single human chromosome in a human-Chinese hamster hybrid cell line, EUBI, following exposure to benomyl. We found a dose-dependent increase in frequency of aneuploidy, but a much more marked induction of polyploidy was noted at the highest benomyl concentration. We confirm the usefulness of this assay for determining genetic risk associated with human exposure to environmental chemicals.