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Published on: May 2, 2013
Mycophenolate mofetil-related pancolitis in a kidney transplant recipient
Mouna Hamouda1, Houda Mahmoudi, Habib Skhiri
1Department of Nephrology, Fattouma Bourguiba Hospital, Monastir, Tunisia. mouuna121@yahoo.fr
Abstract:
Gastrointestinal adverse effects are common with mycophenolate mofetil administration, especially diarrhea. We report a case of mycophenolate mofetil-related colitis in a kidney transplant recipient. Colonoscopy revealed an ulcerative diffuse colitis. The colonoscopic biopsy specimen showed mild crypt distortion, accompanied by cryptitis and focal graft-versus-host disease like changes. The patient's symptoms improved after we discontinued the mycophenolate mofetil. A repeat colonoscopy 2 months after we discontinued the mycophenolate mofetil showed reparative changes. Mycophenolate mofetil is an important drug in organ transplant immune-suppression regimens; however, with its widespread use, additional adverse effects continue to be recognized.
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