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Fibroblast growth factor 23 and Inflammation in CKD
Jair Munoz Mendoza1, Tamara Isakova, Ana C Ricardo
1Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
Summary
Higher fibroblast growth factor 23 (FGF23) levels are linked to increased inflammation in chronic kidney disease (CKD) patients. This suggests FGF23 may play a role in CKD-related inflammatory processes.
Area of Science:
- Nephrology
- Immunology
- Biochemistry
Background:
- Fibroblast growth factor 23 (FGF23) and inflammatory markers are elevated in chronic kidney disease (CKD).
- Both FGF23 and inflammation are associated with adverse clinical outcomes in CKD patients.
Purpose of the Study:
- To test the hypothesis that FGF23 is independently associated with inflammation in patients with CKD.
Main Methods:
- A cross-sectional analysis of 3879 participants from the Chronic Renal Insufficiency Cohort (CRIC) study.
- Assessed the association between FGF23 levels and inflammatory markers: IL-6, C-reactive protein (CRP), TNF-α, and fibrinogen.
Main Results:
- FGF23 showed direct correlations with IL-6, CRP, TNF-α, and fibrinogen (P<0.001).
- Higher FGF23 levels were independently associated with higher inflammatory marker levels and significantly greater odds of severe inflammation (OR, 2.0; P<0.001).
- Each unit increase in lnFGF23 was linked to severe inflammation in multivariable analyses.
Conclusions:
- Elevated FGF23 levels are independently associated with increased inflammation in CKD patients.
- Higher FGF23 is linked to a significantly greater risk of severe inflammation.
- Further research is needed to explore if inflammation modifies the FGF23-adverse outcome relationship in CKD.
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