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Azacitidine-associated Sweet's syndrome.

Hannah B Trickett1, Aaron Cumpston, Michael Craig

  • 1Department of Pharmaceutical Services, West Virginia University Healthcare, Morgantown, 26506, USA. tricketth@wvuhealthcare.com

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|May 5, 2012
PubMed
Summary
This summary is machine-generated.

Sweet's syndrome, a rare skin reaction, can occur during azacitidine therapy for myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). Prompt recognition and corticosteroid treatment lead to symptom resolution.

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Area of Science:

  • Hematology
  • Dermatology
  • Pharmacology

Background:

  • Azacitidine is a hypomethylating agent used to treat myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML).
  • Sweet's syndrome, or acute febrile neutrophilic dermatosis, is an uncommon inflammatory condition characterized by fever, neutrophilia, and characteristic skin lesions.

Observation:

  • Two male patients, one with MDS and another with CMML, developed Sweet's syndrome during azacitidine treatment.
  • Symptoms included a severe erythematous, nodular, and peeling rash, accompanied by chills and fever in one patient.

Findings:

  • Skin biopsies and clinical examinations confirmed Sweet's syndrome in both patients.
  • A strong temporal association was observed between azacitidine initiation and symptom onset.
  • Discontinuation of azacitidine and corticosteroid therapy resulted in prompt symptom resolution.

Implications:

  • This report highlights a rare but significant adverse reaction to azacitidine therapy.
  • Awareness of Sweet's syndrome is crucial for early diagnosis and management in patients receiving azacitidine.
  • Further investigation may be warranted to understand the mechanism of azacitidine-induced Sweet's syndrome.