Related Experiment Video
Updated: May 22, 2026

05:26
Press Needle: A Traditional Chinese Medicine Therapy for Myopia Patients with Dry Eye
Published on: April 12, 2024
Dry eyes can be exacerbated by systemic antihypertensive medication
1Corneo Plastic Unit, Queen Victoria Hospital, East Grinstead, UK.
Scottish Medical Journal
|May 5, 2012
Summary
Systemic antihypertensive medications can cause dry eye disease (DED). Stopping these drugs improved DED symptoms and signs in two patients, highlighting a crucial factor for eye care professionals.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Dry eye disease (DED) is a common and complex ocular condition.
- Identifying all contributing factors to DED is essential for effective management.
Observation:
- Clinicians may overlook systemic medications as a potential cause of DED.
- Two patients presented with DED symptoms and signs linked to antihypertensive drug use.
Findings:
- Discontinuation of systemic antihypertensive medication led to the resolution of DED symptoms and signs in the observed patients.
- This suggests a direct causal link between specific antihypertensive agents and the development of dry eye.
Implications:
- Ophthalmologists should consider systemic medication side effects when diagnosing and treating DED.
- Evaluating patients' medication history is crucial for comprehensive dry eye management.
- This highlights the importance of interdisciplinary communication between physicians managing systemic conditions and eye care providers.
Related Concept Videos
Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
Antihypertensive Drugs: Action of Diuretics
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various tubules...
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
Antihypertensive Drugs: Direct Renin Inhibitors
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
Hypertension II: Pathophysiology
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Alterations in Blood Pressure
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...