[Rectal goblet cell carcinoid. Primary tumor or metastasis?]

Area of Science:

• Gastroenterology
• Oncology
• Pathology

Background:

• Goblet cell carcinoids are rare biphasic neoplasms typically found in the appendix.
• These tumors exhibit both glandular and neuroendocrine differentiation.
• Extraappendiceal goblet cell carcinoids are exceptionally uncommon.

Observation:

• A 60-year-old female presented with a 1.2-cm rectal goblet cell carcinoid.
• The tumor was incidentally discovered during a prophylactic proctocolonoscopy.
• Preoperative staging confirmed no local or systemic spread.

Findings:

• A rectosigmoidectomy was performed due to the aggressive nature of goblet cell carcinoids.
• The patient has remained disease-free for 8 months post-surgery.
• Given a prior appendectomy, the rectal tumor is considered of primary origin.

Implications:

• This case underscores the possibility of primary goblet cell carcinoids in extraappendiceal sites.
• It emphasizes the need for careful evaluation to distinguish primary tumors from appendiceal metastases.
• Prompt surgical intervention and follow-up are crucial for managing these rare gastrointestinal neoplasms.