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Related Experiment Video

Updated: May 22, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Microengineered physiological biomimicry: organs-on-chips.

Dongeun Huh1, Yu-suke Torisawa, Geraldine A Hamilton

  • 1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.

Lab on a Chip
|May 5, 2012
PubMed
Summary
This summary is machine-generated.

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Microscale engineering advances enable

Area of Science:

  • Biotechnology and Biomedical Engineering
  • Microfluidics and Cell Culture Technologies
  • Organoid and Tissue Engineering

Background:

  • Current three-dimensional in vitro models lack the complexity of living organs.
  • Replicating in vivo microenvironments is crucial for accurate physiological studies.
  • Microscale engineering offers novel solutions for advanced cell culture.

Purpose of the Study:

  • To review recent advancements in microscale engineering for creating organ-specific cell culture microenvironments.
  • To highlight the development and potential of 'Organs-on-Chips' technology.
  • To discuss the application of Organs-on-Chips in pharmaceutical and toxicological research.

Main Methods:

  • Development of microfluidic devices with microengineered features.

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Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
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Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
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Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

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Related Experiment Videos

Last Updated: May 22, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
06:30

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

  • Reconstitution of tissue-tissue interfaces and chemical gradients.
  • Integration of dynamic mechanical microenvironments within microfluidic systems.

    • Main Results:

    • Organs-on-Chips successfully recapitulate critical aspects of living organ physiology.
    • These models enable organ-specific physiological studies and specialized in vitro disease modeling.
    • Recent advances focus on enhancing the fidelity of these microengineered systems.

    Conclusions:

    • Organs-on-Chips represent a significant advancement over conventional cell culture and animal testing.
    • This technology holds promise as an alternative for pharmaceutical and toxicology applications.
    • Further development is needed to overcome challenges and realize the full potential for drug development and safety testing.