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Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy
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Off-targeting oft-targeted CD20 in cHL

Leo I Gordon1, Richard Longnecker

  • 1Robert H. Lurie Comprehensive Cancer Center.

Blood
|May 5, 2012
PubMed

We now think of classical Hodgkin lymphoma (cHL) as derived from "crippled" germinal center B cells that have frequently acquired rearranged and somatically mutated Ig genes.1,2 Despite their B-cell origin, the malignant Hodgkin and Reed-Sternberg (HRS) cells have lost most of the superficial trappings of B cells and therefore have been hidden from investigators' lenses for decades, prompting an arduous but persistent race to uncover the mystery of the HRS cell.

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