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Hepatotoxicity of eugenol.
V Soundran1, T Namagiri, S Manonayaki
1Department of Biochemistry, P.S.G. Institute of Medical Sciences & Research, Coimbatore - 641 004, India.
Ancient Science of Life
|May 5, 2012
Summary
Eugenol, a common pharmaceutical, shows liver toxicity in rats. Studies indicate dose-dependent increases in liver enzymes and bilirubin levels, confirming its harmful effects.
Area of Science:
- Pharmacology
- Toxicology
- Biochemistry
Background:
- Eugenol is a widely utilized pharmaceutical compound.
- Understanding its toxicological profile is crucial for safe application.
Purpose of the Study:
- To investigate the potential liver toxicity of eugenol in a rat model.
- To assess the impact of eugenol administration on specific liver enzymes and bilirubin levels.
Main Methods:
- Male albino rats were administered two different doses of eugenol (20 & 30 μg/100g body weight/day) intramuscularly for 10 days.
- Liver function was evaluated by measuring serum enzyme activities (alkaline phosphatase, transaminases, lactate dehydrogenase, glutamyl transferase) and total and differential bilirubin concentrations.
Main Results:
- A dose-dependent increase in total and differential bilirubin fractions was observed.
- Activities of alkaline phosphatase, transaminases, and lactate dehydrogenase showed a dose-dependent increase.
- A decrease in glutamyl transferase activity was noted, suggesting liver damage.
Conclusions:
- Eugenol exhibits toxic effects on the liver in rats.
- The observed changes in liver enzymes and bilirubin levels indicate impaired liver function following eugenol exposure.
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