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Hepatotoxicity of eugenol.

V Soundran¹, T Namagiri, S Manonayaki

¹Department of Biochemistry, P.S.G. Institute of Medical Sciences & Research, Coimbatore - 641 004, India.

Ancient Science of Life

|May 5, 2012

Summary

Eugenol, a common pharmaceutical, shows liver toxicity in rats. Studies indicate dose-dependent increases in liver enzymes and bilirubin levels, confirming its harmful effects.

Area of Science:

Pharmacology
Toxicology
Biochemistry

Background:

Eugenol is a widely utilized pharmaceutical compound.
Understanding its toxicological profile is crucial for safe application.

Purpose of the Study:

To investigate the potential liver toxicity of eugenol in a rat model.
To assess the impact of eugenol administration on specific liver enzymes and bilirubin levels.

Main Methods:

Male albino rats were administered two different doses of eugenol (20 & 30 μg/100g body weight/day) intramuscularly for 10 days.
Liver function was evaluated by measuring serum enzyme activities (alkaline phosphatase, transaminases, lactate dehydrogenase, glutamyl transferase) and total and differential bilirubin concentrations.

Main Results:

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A dose-dependent increase in total and differential bilirubin fractions was observed.
Activities of alkaline phosphatase, transaminases, and lactate dehydrogenase showed a dose-dependent increase.
A decrease in glutamyl transferase activity was noted, suggesting liver damage.

Conclusions:

Eugenol exhibits toxic effects on the liver in rats.
The observed changes in liver enzymes and bilirubin levels indicate impaired liver function following eugenol exposure.