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Evaluation of certain siddha drugs in the treatment of candidiasis

B Suresh1, V R Kalyanaraman, S Dhanashekaran

  • 1Department of Pharmacology, J.S.S. College of Pharmacy, Ootacamund - 643 001, India.

Ancient Science of Life
|May 5, 2012
PubMed

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...