Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
Radical Formation: Overview01:03

Radical Formation: Overview

A bond can be broken either by heterolytic bond cleavage to form ions or homolytic bond cleavage to yield radicals. A fishhook arrow is used to represent the motion of a single electron in homolytic bond cleavage. There are two main sources from which radicals can be formed:
Radicals from spin-paired molecules:
Radicals can be obtained from spin-paired molecules either by homolysis or electron transfer. While two radicals are formed in the former, an electron is added in the latter, also known...
Radical Reactivity: Overview01:11

Radical Reactivity: Overview

Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired molecule. These three...
Radical Formation: Addition00:47

Radical Formation: Addition

Radicals can be formed by adding a radical to a spin-paired molecule. This is typically observed with unsaturated species, where the addition of a radical across the π bond leads to the production of a new radical by dissolving the π bond. For example, the addition of a Br radical to an alkene yields a carbon-centered radical.
Similar to charge conservation in chemical reactions, spin conservation is implicit for radical reactions. Accordingly, the product formed must possess an unpaired...
Radical Reactivity: Steric Effects01:10

Radical Reactivity: Steric Effects

The presence of electron-donating, electron-withdrawing, or conjugating groups adjacent to a radical center, imparts electronic stabilization to the radicals. Examples of such electronically-stabilized radicals are triphenylmethyl, tetramethylpiperidine‐N‐oxide, and 2,2‐diphenyl‐1‐picrylhydrazyl. These radicals are remarkably stable and are known as persistent radicals. Some of the persistent radicals can even be isolated and purified.
Along with electronic factors, steric factors also account...
Radical Reactivity: Electrophilic Radicals01:02

Radical Reactivity: Electrophilic Radicals

Radicals adjacent to electron‐withdrawing groups are called electrophilic radicals. These radicals readily react with nucleophilic alkenes. For example, the malonate radical, in which the radical center is flanked by two electron‐withdrawing groups, reacts readily with butyl vinyl ether, which consists of an electron‐donating oxygen substituent. The reaction between electrophilic malonate radical and nucleophilic vinyl ether is favored because the radical has a low‐energy SOMO, which interacts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bronco T (Shirisadi kasaya), a polyherbal formulation prevents LPS induced septicemia in rats.

European review for medical and pharmacological sciences·2022
Same author

Impact of Nano Preparation of Phytoconstituents in Medulloblastoma.

Methods in molecular biology (Clifton, N.J.)·2022
Same author

Role of Ayurvedic Plants as Anticancer Agents.

Methods in molecular biology (Clifton, N.J.)·2022
Same author

Scoping review on the role and interactions of hydroxytyrosol and alpha-cyclodextrin in lipid-raft-mediated endocytosis of SARS-CoV-2 and bioinformatic molecular docking studies.

European review for medical and pharmacological sciences·2021
Same author

Studies on the inhibitory effect of Strychnos nux vomica-alcohol extract on iron induced lipid peroxidation.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2012
Same author

Effect of Semicarpus anacardium on the cell cycle of DU-145 cells.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2012

Related Experiment Video

Updated: May 22, 2026

A Protocol for Detecting and Scavenging Gas-phase Free Radicals in Mainstream Cigarette Smoke
09:23

A Protocol for Detecting and Scavenging Gas-phase Free Radicals in Mainstream Cigarette Smoke

Published on: January 2, 2012

Free radicals in ayurveda.

Y B Tripathi1

  • 1Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, India.

Ancient Science of Life
|May 5, 2012
PubMed
Summary

Medicinal herb extracts show promise in controlling harmful free radicals. This review highlights recent research advances in this important area of natural product science.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Natural Product Chemistry

Background:

  • Free radicals are reactive species implicated in cellular damage and various diseases.
  • Medicinal herbs have historically been used for therapeutic purposes, with potential antioxidant properties.

Purpose of the Study:

  • To review recent scientific advances in the use of medicinal herb extracts for free radical scavenging.
  • To consolidate current knowledge on the mechanisms and efficacy of herbal antioxidants.

Main Methods:

  • Literature review of peer-reviewed scientific articles.
  • Analysis of studies investigating the antioxidant activity of various medicinal plant extracts.
  • Synthesis of data on phytochemical constituents and their radical-scavenging capabilities.

More Related Videos

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
14:22

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

Published on: April 15, 2013

Related Experiment Videos

Last Updated: May 22, 2026

A Protocol for Detecting and Scavenging Gas-phase Free Radicals in Mainstream Cigarette Smoke
09:23

A Protocol for Detecting and Scavenging Gas-phase Free Radicals in Mainstream Cigarette Smoke

Published on: January 2, 2012

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
14:22

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

Published on: April 15, 2013

Main Results:

  • Numerous medicinal herb extracts exhibit significant free radical scavenging activity.
  • Specific phytochemicals, such as flavonoids and polyphenols, are key contributors to antioxidant effects.
  • Research demonstrates the potential of these extracts in mitigating oxidative stress.

Conclusions:

  • Medicinal herb extracts represent a promising natural source of antioxidants.
  • Further research is warranted to elucidate specific mechanisms and optimize therapeutic applications.
  • The findings support the continued investigation of herbal medicine for managing conditions associated with free radical damage.