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Pharmacological actions of cardipro on cardiovascular system

S Chatterjee1, S N Das, S K Agrawala

  • 1R& D Laboratory, Indian Herbs, Saharanpur - 247 001 Uttar Pradesh, India.

Ancient Science of Life
|May 5, 2012
PubMed

Insights

CARDIPRO, a novel formulation, demonstrates significant cardiovascular benefits. It lowers blood pressure, dilates blood vessels, and enhances heart contractility, offering potential for managing cardiovascular diseases.

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Cardiovascular diseases remain a leading cause of mortality worldwide.
  • There is a continuous need for effective therapeutic agents to manage various cardiovascular disturbances.
  • CARDIPRO is a polyhedral anti-oxidant and cardiotonic formulation proposed for cardiovascular health.

Purpose of the Study:

  • To investigate the pharmacological effects of CARDIPRO on cardiovascular responses.
  • To evaluate its potential as a therapeutic agent for cardiovascular diseases.

Main Methods:

  • In vivo studies: assessed hypotensive effects in dogs and rabbits, and adrenaline potentiation.
  • In vitro studies: examined effects on perfused frog blood vessels, isolated amphibian and mammalian hearts, and isolated rat auricles.
  • Electrocardiogram (ECG) and coronary perfusion flow measurements were conducted.

Main Results:

  • CARDIPRO induced hypotension in dogs and rabbits, an effect blocked by atropine.
  • It potentiated and prolonged adrenaline's hypotensive action.
  • Peripheral vasodilation was observed in frog blood vessels.
  • Positive ionotropic and negative chronotropic effects were noted on isolated hearts.
  • Enhanced contractility in rat auricles and increased coronary perfusion flow in rabbit hearts were observed.
  • No significant per se effect on rabbit ECG.

Conclusions:

  • CARDIPRO exhibits significant cardiotonic, peripheral vasodilating, and coronary vasodilating properties.
  • These combined effects suggest CARDIPRO's potential utility in the management of cardiovascular diseases.

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