Anti bacterials from boerhaavia diffusa

Area of Science:

• Phytochemistry
• Microbiology
• Pharmacology

Background:

• The increasing prevalence of antibiotic resistance necessitates the exploration of novel antimicrobial agents.
• Plant-derived compounds are a promising source for discovering new therapeutic agents.

Purpose of the Study:

• To evaluate the antibacterial potential of chloroform and alcohol extracts from E. plats.
• To identify specific bacterial strains susceptible to these plant extracts and isolated compounds.

Main Methods:

• Screening of chloroform and alcohol extracts against six bacterial species: Staphylococcus aureus, Escherichia coli, Proteus mirabilis, Salmonella typhimurium, Pseudomonas aeruginosa, and Klebsiella aerogenes.
• Fractionation of active extracts using solvent elution (benzene-ethyl acetate, n-butanol).
• Isolation and testing of a phenolic compound from an active fraction.

Main Results:

• The benzene-ethyl acetate eluate of the chloroform extract demonstrated activity against Escherichia coli, Salmonella typhimurium, and Pseudomonas aeruginosa.
• The n-butanol extract of the alcohol extract was effective against Proteus mirabilis and Salmonella typhimurium.
• A purified phenolic compound showed activity exclusively against Proteus mirabilis.

Conclusions:

• E. plats extracts possess significant antibacterial properties against a range of Gram-negative bacteria.
• The isolated phenolic compound warrants further investigation as a potential therapeutic agent for Proteus mirabilis infections.