Anti histaminic activity of cissus quadragularis

Area of Science:

• Pharmacology
• Natural Product Research
• Inflammation Studies

Background:

• Histamine plays a key role in inflammatory responses.
• Cissus quadrangularis is a traditional medicinal plant with various reported bioactivities.
• Investigating natural compounds for anti-inflammatory properties is crucial for developing new therapeutics.

Purpose of the Study:

• To evaluate the antihistaminic and anti-inflammatory effects of Cissus quadrangularis stem powder.
• To determine the impact of the plant extract on histamine activity and content in vivo.
• To compare its efficacy against standard anti-inflammatory drugs.

Main Methods:

• Carrageenan-induced rat paw edema model was used to assess swelling and histamine activity.
• Formalin-induced peritonitis model in rats was employed to measure histamine content in peritoneal fluid.
• Crude Cissus quadrangularis stem powder was administered at a dose of 100mg/1000gm.

Main Results:

• The Cissus quadrangularis stem powder significantly reduced swelling in the early phase of carrageenan-induced inflammation by up to 44%.
• The extract also significantly decreased histamine levels in the peritoneal fluid during formalin-induced peritonitis.
• Hydrocortisone and Avil were used as standard drugs for comparative analysis.

Conclusions:

• Cissus quadrangularis stem powder possesses significant antihistaminic and anti-inflammatory properties.
• The findings support the traditional use of Cissus quadrangularis for inflammatory conditions.
• Further research into the active constituents and mechanisms of action is warranted.