Effect of hyperlipidaemia on reproductive organs in male albino rabbits : a histological approach

The present study was aimed to study the effects of hyperlipidaemia on the histology of various reproductive organs. The chronic oral administration of cholesterol diet (400 mg/kg bodyweight/day for 60 day) induced hyperlipidaemia in male rabbits. It showed severe degeneration in germinal epithelium. Few spermatocytes could be seen, but the number was decreased. The seminiferous tubules were wavy and shrunken. As the tubule had large number of primary spermatocytes, it seems that the meiotic divisions were inhibited. Leydig cells nuclei were shrunken and the distribution of Leydig cells was abnormal. The histoarchitecture of cauda epididymis showed lesser number of spermatozoa in lumen and shrinkage was observed in epithelial cell line.