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Amelioration of mercuric chloride induced nephrotoxicity and oxidative stress by garlic extract
1PG and Research Department of Biochesmistry, Dr. N.G.P. Arts and Science College, Kovai Medical Centre for Research and Education Trust, Coimbatore -641 035, Tamilnadu, India.
Abstract:
Effect of Garlic against mercuric chloride induced toxicity in albino rats was studied. Oral administration of mercuric chloride (100mg/kg/p.o) for 30 days resulted in significant increase in LPO Basal level and LPO FeSO(4) induced and significant decrease in GSH (Glutathione) and Vit C as compared to the normal and control group. Simultaneous administration of Garlic along with Mercuric chloride, produced a pronounced neproprotective effect against mercuric chloride induced toxicity in rats by restoring the normal levels of biochemical parameters.
