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Updated: May 22, 2026

Gastrointestinal Motility Monitor (GIMM)
Published on: December 1, 2010
Effect of nimbidin on gastric Acid secretion
1C. D. R. S. Pharmacological Unit, Dept. of Pharmacology Medical College, Trivandrum - 695 011, India.
Abstract:
Nimbidin, the crude bitter compound from neem has been investigated for its gastric anti secretory activity in rats and cats. It exhibited significant anti - secretory activity in pylorus ligated rats and cats. In lumen - perfused rats it suppressed the basal as well as histamine and carbachol stimulated gastric acid output at 40 mg/kg (i.v). However it had no effect on ASA - induced back - diffusion of H+ ions. This anti secretory activity of nimbidin was found to be similar to that of H2 - receptor antagonists, which are reported to suppress the histamine induced gastric secretion in animals and man.
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