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Calotropin - a novel compound for fertility control
R S Gupta1, N Sharma, V P Dixit
1Reproduction Physiology, Section, Department of Zoology, University of Rajasthan, Jaipur - 302 004.
Ancient Science of Life
|May 5, 2012
Summary
Calotropin from Calotropis procera inhibits male fertility by disrupting spermatogenesis in gerbils and rabbits. This compound also demonstrated abortifacient activity in pregnant female rats.
Area of Science:
- Pharmacology
- Reproductive Biology
- Ethnobotany
Background:
- Calotropis procera is a plant used in traditional medicine.
- Calotropin is a compound isolated from Calotropis procera roots.
Purpose of the Study:
- To investigate the effects of Calotropin on spermatogenesis in male animals.
- To evaluate the abortifacient activity of Calotropin in female rats.
Main Methods:
- Calotropin was administered daily to gerbils and rabbits for 30 days.
- Spermatogenesis, Leydig cell production, and testicular biochemistry were assessed.
- Pregnant rats were treated with Calotropin to determine abortifacient effects.
Main Results:
- Calotropin significantly inhibited spermatogenesis, depleting spermatids by up to 94%.
- Testicular and Leydig cell sizes were reduced, indicating diminished androgenesis.
- Calotropin induced abortion in pregnant rats on the 12th day of gestation.
Conclusions:
- Calotropin effectively inhibits spermatogenesis in male mammals.
- Calotropin exhibits abortifacient properties in female rats.
- Calotropin holds potential as a male contraceptive and an agent for medical abortion.
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