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Updated: May 22, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
Regeneration potential of pulp-dentin complex: Systematic review.
1Department of Pedodontics and Preventive Dentistry, Saveetha Dental College and Hospital, Chennai, Tamil Nadu, India.
Tissue engineering strategies offer promising new approaches for regenerating tooth tissues, potentially replacing traditional treatments like apexification with apexogenesis. This review explores these advancements in restorative dentistry.
Area of Science:
- Regenerative medicine
- Biomaterials science
- Dental research
Background:
- Tissue engineering integrates stem cells, morphogens, and scaffolds for functional tooth regeneration.
- Clinical reports suggest apexogenesis may replace apexification for certain dental cases.
- This review focuses on tissue engineering strategies for tooth regeneration.
Purpose of the Study:
- To review and discuss current tissue engineering strategies for tooth tissue regeneration.
- To highlight the potential of tissue engineering in restorative dentistry.
Main Methods:
- Comprehensive literature search using Entrez Pubmed and Cochrane Central Register.
- Predetermined inclusion and exclusion criteria applied to 1619 initial papers.
- 31 selected papers (27 full-text, 4 abstracts) formed the basis of the review.
Main Results:
- The review synthesized data from 31 selected scientific papers.
- Identified key elements and emerging possibilities in tooth tissue regeneration.
Conclusions:
- Tissue engineering demonstrates significant promise in dentistry.
- Offers potential for ideal restorations to replace lost tooth structure.
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