Inflammatory linear verrucous epidermal nevus syndrome with its polymorphic presentation - A rare case report

Area of Science:

• Dermatology
• Medical Genetics
• Clinical Medicine

Background:

• Epidermal nevi are congenital hamartomas.
• Epidermal nevus syndromes involve systemic manifestations in one-third of cases.
• Four distinct syndromes are recognized based on nevus type.

Observation:

• A rare case of inflammatory linear verrucous epidermal nevus (ILVEN) syndrome is presented.
• The patient is a 23-year-old female.
• The patient exhibits a wide spectrum of mucosal, cutaneous, and skeletal abnormalities.

Findings:

• Inflammatory linear verrucous epidermal nevus syndrome can present with diverse systemic abnormalities.
• The case demonstrates the polymorphic nature of ILVEN syndrome.
• Mucosal, cutaneous, and skeletal systems were involved in this patient.

Implications:

• Recognizing the systemic associations of ILVEN syndrome is crucial for comprehensive patient management.
• This case underscores the importance of a multidisciplinary approach in diagnosing and treating complex epidermal nevus syndromes.
• Further research into the genetic and molecular underpinnings of these syndromes may reveal novel therapeutic targets.