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Related Experiment Video

Updated: May 22, 2026

Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems
08:17

Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems

Published on: July 4, 2011

Subcellular carrier-based optical ion-selective nanosensors.

Susana Carregal-Romero1, Jose-Maria Montenegro, Wolfgang J Parak

  • 1Department of Biophotonics, Institute of Physics and WZMW, Philipps University of Marburg Marburg, Germany.

Frontiers in Pharmacology
|May 5, 2012
PubMed
Summary

This review discusses two nanotechnology-based carrier systems for non-invasive, real-time sensing of intracellular analytes. These systems, inorganic nanoparticles and organic microcapsules, offer distinct cellular localization and sensing capabilities.

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Cellular Biology

Background:

  • Real-time intracellular sensing is crucial for understanding cellular processes.
  • Existing sensing methods often face limitations in non-invasiveness and specificity.
  • Nanotechnology offers novel platforms for developing advanced biosensors.

Purpose of the Study:

  • To review two distinct nanotechnology-based carrier systems for non-invasive intracellular sensing.
  • To compare the properties, cellular localization, and sensing capabilities of these systems.
  • To explore future directions for sophisticated sensor development.

Main Methods:

  • Discussion of inorganic nanoparticles with organic coatings as a carrier system.
  • Discussion of organic microcapsules as an alternative carrier system.
Keywords:
cellscolloidal nanoparticlesionsmolecular imagingnon-invasiveoptical read-outpolyelectrolyte multilayer capsulessensors

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Last Updated: May 22, 2026

Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems
08:17

Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems

Published on: July 4, 2011

Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
09:23

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

  • Analysis of optical read-out mechanisms and ratiometric measurements.

    • Main Results:

    • Nanoparticles and microcapsules exhibit different cellular internalization patterns due to size and physicochemical properties.
    • Nanoparticles localize primarily in endolysosomal compartments, while microcapsules are found in phagolysosomal vesicles.
    • Microcapsules offer multiplexing capabilities, which nanoparticles lack.

    Conclusions:

    • Two distinct nanotechnology-based sensor systems provide unique tools for intracellular analyte detection.
    • The differential localization and sensing abilities of nanoparticles and microcapsules allow for targeted cellular analysis.
    • Confining nanoscale sensors within microcapsules presents a promising avenue for creating highly sophisticated biosensing platforms.