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Updated: May 22, 2026

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
05:06

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

Interleukin-1 receptor antagonist gene polymorphism in patients with multidrug-resistant Acinetobacter

Min-Jer Hsu1, Yun-Chieh Lu, Yu-Chang Hsu

  • 1Department of Pulmonary, Antai Tian, Sheng Memorial Hospital, Taiwan.

Annals of Thoracic Medicine
|May 5, 2012
PubMed
Abstract

Insights

Interleukin-1 receptor antagonist (IL-1ra) gene polymorphism is linked to multidrug-resistant Acinetobacter baumannii pneumonia. This finding may help predict pneumonia risk in patients.

Area of Science:

  • Medical Genetics
  • Infectious Diseases
  • Pulmonology

Background:

  • Multidrug-resistant Acinetobacter baumannii (MDRAB) pneumonia presents significant therapeutic challenges in healthcare settings.
  • Interleukin-1 receptor antagonist (IL-1ra) plays a crucial role in the host immune response during pneumonia.

Purpose of the Study:

  • To investigate the association between variable nucleotide tandem repeat polymorphism in the IL-1ra gene and MDRAB-related pneumonia.

Main Methods:

  • Genotyping of the IL-1ra gene using polymerase chain reaction, restriction fragment length polymorphism, and agarose gel electrophoresis.
  • Comparison of IL-1ra genotypes between 36 MDRAB pneumonia patients and 30 non-MDRAB pneumonia controls.

Main Results:

  • A statistically significant difference in IL-1ra genotype frequencies was observed between MDRAB pneumonia cases and controls (P < 0.05).
  • The IL-1ra A1 allele frequency was significantly increased in patients with MDRAB-related pneumonia (P < 0.05).

Conclusions:

  • IL-1ra gene polymorphism is associated with an increased risk of developing MDRAB-related pneumonia.
Keywords:
Acinetobacter baumanniiIL-1rapneumoniapolymorphism

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