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08:54
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
Liver directed therapy for renal cell carcinoma
Russell C Langan1, R Taylor Ripley, Jeremy L Davis
11. Surgery Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Journal of Cancer
|May 5, 2012
Summary
Liver-directed therapy for metastatic renal cell carcinoma (RCC) to the liver is safe and effective for selected patients. Metachronous metastases, in particular, are associated with prolonged survival when treated with surgery or radiofrequency ablation.
Area of Science:
- Oncology
- Surgical Oncology
- Interventional Radiology
Background:
- Metastatic renal cell carcinoma (RCC) to the liver presents a significant challenge with poor prognosis.
- Liver-directed therapies for metastatic RCC are controversial, necessitating criteria for patient selection.
Purpose of the Study:
- To identify patient selection criteria for liver-directed therapy in metastatic RCC.
- To evaluate the safety and efficacy of liver-directed treatments for RCC liver metastases.
Main Methods:
- Retrospective analysis of 247 consecutive patients with RCC metastatic to the liver.
- Evaluation of liver resection and radiofrequency ablation (RFA) outcomes.
- Analysis of patient survival and progression-free survival based on treatment and disease characteristics.
Main Results:
- Seven percent (18/247) of patients received liver-directed therapy (resection or RFA), with 0% mortality.
- Metachronous liver metastases were associated with significantly prolonged survival (p=0.02).
- One, three, and five-year actuarial survival rates were 89%, 40%, and 27%, respectively.
Conclusions:
- Liver-directed therapy is a safe and viable option for highly selected patients with metastatic RCC to the liver.
- A multidisciplinary approach is recommended for considering liver-directed therapy, especially for metachronous metastases.
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