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The histopathological spectrum of human meningiomas

Thomas Backer-Grøndahl1, Bjørnar H Moen, Sverre H Torp

  • 1Department of Laboratory Medicine, Children's and Women's Health, Trondheim University Hospital, NTNU, Trondheim, Norway.

International Journal of Clinical and Experimental Pathology
|May 5, 2012
PubMed

Insights

Histopathological grading of meningiomas provides prognostic insights but faces interobserver variability. The WHO 2007 classification increased atypical (grade II) meningioma diagnoses, highlighting the need for revised diagnostic criteria.

Area of Science:

  • Neuropathology
  • Oncology
  • Medical Diagnostics

Background:

  • Histopathological grading of meningiomas is crucial for prognosis.
  • Interobserver variability affects meningioma grading accuracy.
  • Previous World Health Organization (WHO) classifications have limitations.

Purpose of the Study:

  • To examine the frequency of meningioma grades (I, II, III) using different WHO classifications.
  • To analyze histopathological features and their correlations.
  • To assess the impact of the WHO 2007 classification on meningioma grading.

Main Methods:

  • Retrospective review of histopathological sections from 196 primary human meningioma patients.
  • Analysis of established grading criteria and their correlation with tumorigenesis.
  • Comparison of meningioma grade frequencies across different WHO classification schemes.

Main Results:

  • The WHO 2007 classification led to a significant increase in atypical (grade II) meningiomas (30%), primarily due to classifying brain-infiltrating tumors as grade II.
  • Established grading criteria showed significant correlation with tumorigenesis.
  • A bimodal frequency distribution was observed in age groups of females.

Conclusions:

  • The WHO 2007 classification impacts meningioma grading, particularly for infiltrating types.
  • Continuous revision of histopathological classification systems is essential for improving diagnostic accuracy.
  • Further research into meningioma histopathology and classification is warranted.
Keywords:
Brain tumorsClemmesen’s hookclassificationdiagnosisgrading

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