Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revealing the biomolecular response of glioma cells to helium, carbon and oxygen minibeam radiation therapy using synchrotron-based infrared microspectroscopy.

The Analyst·2026
Same author

Correction: Synchrotron-based infrared microspectroscopy unveils the biomolecular response of healthy and tumour cell lines to neon minibeam radiation therapy.

The Analyst·2025
Same author

Synchrotron-based infrared microspectroscopy unveils the biomolecular response of healthy and tumour cell lines to neon minibeam radiation therapy.

The Analyst·2024
Same author

Dosimetric feasibility study ("proof of concept") of refractory ventricular tachycardia radioablation using proton minibeams.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2024
Same author

RadioTransNet, Radiotherapy Translational and Preclinical Research Network: Results from the dedicated French cancer institute (INCa) call for projects.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2023
Same author

Novel unconventional radiotherapy techniques: Current status and future perspectives - Report from the 2nd international radiation oncology online seminar.

Clinical and translational radiation oncology·2023

Related Experiment Video

Updated: May 22, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Monte Carlo-based treatment planning system calculation engine for microbeam radiation therapy.

I Martinez-Rovira1, J Sempau, Y Prezado

  • 1Institut de Tècniques Energètiques, Universitat Politècnica de Catalunya, Barcelona, Spain. immamartinez@gmail.com

Medical Physics
|May 8, 2012
PubMed
Summary

A new Monte Carlo (MC) calculation engine for microbeam radiation therapy (MRT) treatment planning systems (TPS) has been developed. This tool enables accurate dose calculations for upcoming clinical trials in pet radiotherapy.

More Related Videos

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources
05:18

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Related Experiment Videos

Last Updated: May 22, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources
05:18

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Area of Science:

  • Medical Physics
  • Radiotherapy
  • Biomedical Engineering

Background:

  • Microbeam radiation therapy (MRT) is an advanced synchrotron radiotherapy technique utilizing narrow, precisely spaced beams.
  • Preclinical studies demonstrate MRT's efficacy in eradicating aggressive tumors while sparing healthy tissue.
  • Upcoming clinical trials at the European Synchrotron Radiation Facility (ESRF) necessitate accurate dose calculations for MRT.

Purpose of the Study:

  • To develop a specialized Monte Carlo (MC)-based calculation engine for an MRT treatment planning system (TPS).
  • To address the unique beam generation and irradiation geometry challenges of MRT compared to conventional radiotherapy.
  • To enable accurate dose calculations for preclinical and clinical applications, starting with pet treatments.

Main Methods:

  • Utilized the PENELOPE/PENEasy MC code with a realistic beam source model for dose distribution computation.
  • Performed experimental verification using radiochromic films in heterogeneous phantoms.
  • Implemented CT image-based patient modeling, decoupling voxel grids for micrometer-level dose calculations, and employed optimization techniques (variance reduction, parallelization) to reduce computation time.

Main Results:

  • Achieved good agreement between MC simulations and experimental data, including at interfaces between different materials.
  • Significant reduction in computation time through simulation parameter optimization and variance reduction techniques.
  • Parallelization further decreased calculation time to approximately 1 day for a typical MRT clinical case, demonstrated with a dog head treatment example.

Conclusions:

  • Successfully developed the first MC-based calculation engine for MRT TPS, crucial for upcoming clinical trials at ESRF.
  • The MC engine accurately calculates dose distributions in micrometer-sized bins within complex, voxelized CT structures in a practical timeframe.
  • Optimized computation times are suitable for pet radiotherapy, with future integration into a user-friendly graphical interface planned.