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Autoimmune T cells lured to a FASL web of death by MSCs

William J Murphy1, Jan A Nolta

  • 1Department of Dermatology, University of California, Davis, Davis, CA 95616, USA. wmjmurphy@ucdavis.edu

Cell Stem Cell
|May 8, 2012
PubMed

Achieving immune tolerance through cell transplantation is a promising approach for treating autoimmune disease. In this issue of Cell Stem Cell, Akiyama et al. (2012) demonstrate that human and mouse mesenchymal stem cells can induce immune suppression by attracting and killing autoreactive T cells, which stimulates TGFb production by macrophages and generates regulatory T cells.

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