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Updated: Dec 18, 2025

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
Levetiracetam-associated loss of libido and anhedonia
Rocco S Calabrò1, Domenico Italiano, David Militi
1IRCCS Centro Neurolesi Bonino-Pulejo Messina, Italy. salbro77@tiscali.it
Abstract:
The relationship between the older antiepileptic drugs (AEDs) and sexual dysfunction has long been known and it is likely to be related to sexual hormonal changes. Instead, rare reports on sexual disorders related to new AEDs suggest the possibility of complex and poorly understood mechanisms, mainly involving central nervous system neurotransmitters such as glutamate, serotonin, and dopamine. Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake.
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