Related Experiment Video
Updated: May 22, 2026

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
Published on: November 11, 2022
A case of spontaneous coronary artery dissection: it is not always plaque rupture
Sohil Pothiawala1, Fatimah Lateef
1Department of Emergency Medicine, Singapore General Hospital, Singapore.
Insights
Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome (ACS). Early diagnosis via urgent angiography is crucial for improving patient outcomes in suspected SCAD cases.
Area of Science:
- Cardiology
- Vascular Medicine
Background:
- Spontaneous coronary artery dissection (SCAD) is an uncommon cause of acute coronary syndrome (ACS).
- SCAD presentation varies widely, from angina to sudden death, with no established standard therapy.
- SCAD mimics ACS and should be considered in younger patients presenting with ACS, even without traditional risk factors.
Background:
Spontaneous coronary artery dissection (SCAD) is an extremely rare cause of acute coronary syndrome (ACS). Patients may present with a broad spectrum of clinical scenarios, ranging from angina pectoris to myocardial infarction, cardiogenic shock, and sudden death. Standard therapy has not been established; current treatments range from conservative management to percutaneous revascularization or coronary artery bypass surgery.
Objective:
SCAD greatly mimics ACS, and this diagnosis should be considered when evaluating young patients who present with ACS with or without classical risk factors for coronary artery disease.
Case Report:
We report a case of a 45-year old man who presented with chest pain typical of ACS. He had no risk factors except for a smoking history of 2.5 pack-years. Once the clinical findings suggested acute inferolateral myocardial infarction, the patient underwent emergent cardiac catheterization, which revealed left anterior descending coronary artery dissection. This in itself is not a common cause of inferolateral ST elevation changes on electrocardiogram.
Conclusion:
This case highlights the fact that although SCAD is a rare entity, it is increasingly being recognized as a significant cause of ACS. Urgent angiography should be considered if SCAD is suspected, because early diagnosis and appropriate management significantly improve the outcome in these patients.
Related Concept Videos
Coronary Artery Disease II: Pathophysiology
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Acute Coronary Syndrome I: Introduction
Peripheral Artery Disease I: Introduction
Atherosclerosis I: Introduction
Coronary Artery Disease I: Introduction
