Related Experiment Video

Updated: May 22, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

A simple multiplier to calculate the impact of HDL cholesterol on cardiovascular risk estimation using SCORE

Olivier S Descamps1, Marie Therese Cooney, Guy De Backer

  • 1Département de Médecine Interne et Centre de Recherche Médicale de Jolimont, Hôpital de Jolimont, Haine Saint-Paul, Belgium. olivierdescamps@hotmail.com

Atherosclerosis
|May 8, 2012
PubMed

Insights

Calculating cardiovascular disease risk is simplified using a new method that adjusts for high-density lipoprotein cholesterol (HDL-C) levels. This approach avoids multiple charts, making risk assessment easier and more accurate.

Area of Science:

  • Cardiology
  • Lipidology
  • Public Health

Background:

  • The 2011 ESC-EAS guidelines for dyslipidaemia management utilize multiple charts to depict cardiovascular disease (CVD) risk associated with varying high-density lipoprotein cholesterol (HDL-C) levels.
  • Accurate CVD risk assessment is crucial for effective patient management and preventative strategies.

Purpose of the Study:

  • To develop a simplified method for calculating the impact of different HDL-C levels on CVD risk.
  • To streamline the application of ESC-EAS guidelines for risk stratification.

Main Methods:

  • Derived HDL-C and sex-specific multipliers to adjust CVD risk.
  • Applied these multipliers to reference charts for risk estimation.
  • Evaluated three distinct strategies for risk calculation.

Main Results:

  • One strategy, utilizing a low HDL-C (0.8 mmol/l) reference chart, proved to be the simplest and acceptably accurate.
  • This simplified approach effectively integrates HDL-C level impact into CVD risk estimation.

Conclusions:

  • A single, simplified reference chart approach can accurately estimate CVD risk, accounting for HDL-C levels.
  • This method reduces complexity compared to using multiple charts, facilitating broader clinical application.

More Related Videos

High-Density Lipoprotein-Specific Phospholipid Efflux Assay07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Hazard Ratio01:12

Hazard Ratio

The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial evaluating a...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...