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Laboratory testing in pediatric rheumatology
1Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY 10467, USA. jmehta@montefiore.org
Insights
Laboratory tests are crucial for diagnosing and monitoring pediatric rheumatic diseases. This review covers essential tests, including blood counts and autoantibodies, aiding pediatricians and rheumatologists.
Area of Science:
- Pediatric Rheumatology
- Clinical Laboratory Science
Background:
- Laboratory evaluations are vital for managing pediatric rheumatic diseases.
- Tests aid in screening, diagnosis, monitoring disease activity, and predicting prognosis.
Purpose of the Study:
- To review the utility and interpretation of common laboratory tests in pediatric rheumatology.
- To cover tests used by general pediatricians and pediatric rheumatology clinics.
Main Methods:
- Literature review of studies on laboratory evaluations in pediatric rheumatic diseases.
- Discussion of commonly ordered tests: complete blood count, acute phase reactants, autoantibodies, serum complement, urinalysis, streptococcal antibody tests, and genetic studies.
Main Results:
- Laboratory tests play a key role in the diagnostic and management pathway for children with rheumatic conditions.
- Interpretation of results guides treatment decisions and prognosis assessment.
Conclusions:
- Comprehensive understanding of laboratory test interpretation is essential for effective pediatric rheumatology care.
- These evaluations support evidence-based management strategies for pediatric rheumatic diseases.
Abstract:
In children, laboratory evaluations can assist in the screening of patients for inflammatory disorders, confirm diagnoses, allow for monitoring of disease activity and response to therapy, and suggest prognoses and risk of morbidities associated with rheumatic diseases. This review provides an overview of the usefulness and interpretation of both the commonly ordered tests ordered by the general pediatrician as well as those frequently used in the pediatric rheumatology clinic for diagnosis and disease monitoring. Studies discussed include the complete blood count, acute phase reactants, autoantibodies, serum complement, urinalysis, streptococcal antibody tests, and commonly used genetic studies.
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