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Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
08:12

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Beyond the genome and proteome: targeting protein modifications in cancer

Anatoliy Markiv1, Neela Devi Sing Rambaruth, Miriam Victoria Dwek

  • 1Department of Molecular and Applied Biosciences, School of Life Sciences, University of Westminster, London W1W 6UW, United Kingdom.

Current Opinion in Pharmacology
|May 8, 2012
PubMed

Insights

Post-translational modifications (PTMs) are crucial in cancer biology. Targeting these protein alterations or the enzymes involved offers new therapeutic strategies for cancer treatment.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Post-translational modifications (PTMs) are essential for protein function.
  • Understanding PTMs is critical for advancing cancer cell biology.
  • Aberrant PTMs are frequently observed in various cancers.

Purpose of the Study:

  • To highlight the significance of PTMs in cancer.
  • To discuss the known PTMs and their roles in cancer.
  • To explore potential therapeutic strategies targeting PTMs in cancer.

Main Methods:

  • Review of existing literature on PTMs in cancer.
  • Analysis of key cellular pathways affected by PTMs.
  • Identification of therapeutic approaches targeting PTMs.

Main Results:

  • Common PTMs like glycosylation, phosphorylation, ubiquitination, methylation, and palmitylation are altered in cancer.
  • These modifications impact critical cancer pathways such as signal transduction and protein interactions.
  • Altered PTMs affect cell membrane receptor function.

Conclusions:

  • PTMs represent a significant area for cancer research and therapeutic development.
  • Targeting PTMs, their enzymes, or leveraging host immunity are promising strategies.
  • Further research into PTMs will likely yield novel cancer treatments.

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