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Updated: May 22, 2026

Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle
Published on: May 5, 2022
Smooth muscle in tissue remodeling and hyper-reactivity: airways and arteries
Kristina Rydell-Törmänen1, Paul-André Risse, Varsha Kanabar
1Unit of Lung Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Abstract:
Smooth muscle comprises a key functional component of both the airways and their supporting vasculature. Dysfunction of smooth muscle contributes to and exacerbates a host of breathing-associated pathologies such as asthma, chronic obstructive pulmonary disease and pulmonary hypertension. These diseases may be marked by airway and/or vascular smooth muscle hypertrophy, proliferation and hyper-reactivity, and related conditions such as fibrosis and extracellular matrix remodeling. This review will focus on the contribution of airway or vascular smooth dysfunction to common airway diseases.
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