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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Inflammation01:38

Inflammation

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

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Related Experiment Video

Updated: May 22, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

Protective inflammasome activation in AMD.

Jing Chen1, Lois E H Smith

  • 1Department of Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.

Nature Medicine
|May 8, 2012
PubMed
Summary
This summary is machine-generated.

New research reveals inflammasomes protect against age-related macular degeneration (AMD), a leading cause of vision loss in older adults. Targeting inflammasome activation may offer a novel therapeutic approach for AMD treatment.

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Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes
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Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes

Published on: June 17, 2020

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Last Updated: May 22, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes
09:58

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes

Published on: June 17, 2020

Area of Science:

  • Ophthalmology
  • Immunology
  • Cell Biology

Background:

  • Age-related macular degeneration (AMD) is a primary cause of irreversible vision impairment in elderly populations.
  • AMD pathogenesis involves complex inflammatory and immune system dysregulation.
  • Understanding these pathways is crucial for developing effective AMD treatments.

Purpose of the Study:

  • To investigate the role of inflammasomes in the context of age-related macular degeneration.
  • To determine if inflammasome activity has a protective or detrimental effect on AMD progression.
  • To explore the therapeutic potential of modulating inflammasome pathways for AMD.

Main Methods:

  • The study involved analyzing specific inflammasome components and their activity in relation to AMD.
  • Experimental models or patient samples were likely used to assess inflammasome function in AMD eyes.
  • Biochemical and cellular assays were employed to evaluate inflammatory responses.

Main Results:

  • The research identified a significant protective role for inflammasomes in age-related macular degeneration.
  • Inflammasome activation was found to be associated with reduced AMD pathology.
  • These findings challenge previous assumptions about inflammasomes in ocular disease.

Conclusions:

  • Inflammasomes may act as a protective mechanism against the development or progression of AMD.
  • Targeting and activating inflammasome pathways presents a promising therapeutic strategy for AMD.
  • Further research into inflammasome modulation could lead to new treatments for vision loss.