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Updated: May 22, 2026

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
Published on: April 8, 2020
Polyelectrolyte based molecular carriers: the role of self-assembled proteins in permeability properties
Neda Habibi1, Laura Pastorino, Oscar Herrera Sandoval
1Department of Communication, Computer and System Sciences, Nanobiotechnology and Medical Informatics Laboratory, University of Genova, Genova, Italy.
Abstract:
Polyelectrolyte capsules are seen as promising nanotechnology based drug delivery systems. In previous works, we have demonstrated the possibility to fabricate bio-activated surface layer containing capsules with improved features in terms of biocompatibility. In this study, we have characterized the permeability properties of such capsules towards low and high molecular weight molecules, including proteins. The results indicated that the presence of the surface layer strongly affects the permeability properties of the capsules in terms of loading capacity which was found to be higher compared to that of plain capsules. These properties make such systems interesting candidates as drug delivery platforms.
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