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High urinary bisphenol A concentrations in workers and possible laboratory abnormalities.
Feng Wang1, Jing Hua, Minjian Chen
1Department of Public Health, Gulou District Hua Qiao Road Community Health Service Center, Nanjing, China.
Occupational and Environmental Medicine
|May 8, 2012
Summary
Occupational exposure to Bisphenol A (BPA) in Chinese epoxy resin workers was linked to elevated urinary BPA levels. Higher BPA concentrations correlated with abnormal thyroid hormone levels, suggesting potential disruption.
Area of Science:
- Environmental Health
- Occupational Medicine
- Toxicology
Background:
- Bisphenol A (BPA) is a common chemical used in epoxy resins in China.
- Limited research exists on the adverse health effects of occupational BPA exposure.
- This study investigates the health status of workers exposed to BPA in epoxy resin factories.
Purpose of the Study:
- To examine the association between urinary Bisphenol A (BPA) concentrations in occupational settings.
- To assess the relationship between BPA levels and various laboratory health parameters in workers.
Main Methods:
- Cross-sectional analysis of spot urine samples collected at the end of shifts from 28 workers in two semiautomatic epoxy resin factories.
- Measurement of urinary BPA concentrations, adjusted for urine creatinine.
- Analysis of blood and urinary markers for liver function, glucose homeostasis, thyroid function, and cardiovascular health.
Main Results:
- Average adjusted urinary BPA concentration was 31.96 μg/g creatinine, with significant variations among job roles.
- Higher urinary BPA concentrations were associated with clinically abnormal levels of thyroid hormones (FT3, FT4, TT3, TT4) and liver enzymes (AST, GGT).
- A significant positive linear trend was observed between higher BPA concentrations and increased FT3 levels (p<0.001).
Conclusions:
- Elevated occupational exposure to Bisphenol A (BPA), indicated by urinary BPA levels, is potentially associated with thyroid hormone disruption.
- Further research is warranted to understand the full spectrum of health effects from occupational BPA exposure.
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