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Updated: May 22, 2026
12:12
Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice
Published on: February 8, 2016
Microbial steroid transformations: current state and prospects.
Marina V Donova1, Olga V Egorova
1G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, pr. Nauki 5, Pushchino, Moscow Region 142290, Russia. donova-marina@rambler.ru
Applied Microbiology and Biotechnology
|May 8, 2012
Summary
Microbial whole-cell biocatalysis advances steroid modification, enhancing pharmaceutical production. This review covers key reactions, process improvements, and future prospects in white biotechnology.
Area of Science:
- Biotechnology
- Microbiology
- Organic Chemistry
Background:
- Microbial steroid modification is a key area in white biotechnology.
- Recent advances in genetic engineering and process monitoring have significantly improved this field.
- This review focuses on developments since 2003.
Purpose of the Study:
- To summarize recent advancements in microbial steroid conversion.
- To highlight key microbial reactions for steroid functionalization.
- To discuss methods for enhancing bioprocesses and their applications in the pharmaceutical industry.
Main Methods:
- Literature review of studies on microbial steroid conversion since 2003.
- Analysis of key microbial reactions: sterol side-chain degradation, hydroxylation, and redox reactions.
- Evaluation of methods for improving bioprocess productivity and selectivity.
Main Results:
- Detailed overview of microbial steroid functionalization techniques.
- Identification of methods to enhance bioprocess efficiency and specificity.
- Examples of microbial transformations for producing pharmaceutical ingredients and precursors.
Conclusions:
- Whole-cell biocatalysis offers significant potential for the steroid industry.
- Continued research in genetic engineering and process optimization is crucial.
- Microbial steroid conversion is a sustainable route for valuable compound synthesis.
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