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Correlation between serum H2S and pulmonary function in children with bronchial asthma
Man Tian1, Yu Wang, Yue-Qing Lu
1Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing, Jiangsu 210008, PR China. tmsweet2012@126.com
Molecular Medicine Reports
|May 8, 2012
Summary
Children with asthma have lower serum hydrogen sulfide (H2S) levels, which correlate with reduced lung function. This suggests H2S may be a biomarker for asthma severity in pediatric patients.
Area of Science:
- Biochemistry
- Pulmonology
- Pediatrics
Background:
- Endogenous hydrogen sulfide (H2S) is recognized as an inflammatory mediator.
- The role of H2S in asthma pathogenesis, particularly in airway remodeling, remains under-researched.
- Asthma affects children's lung function, but the specific involvement of H2S is unclear.
Purpose of the Study:
- To investigate the correlation between serum H2S concentration and pulmonary function in children with asthma.
- To compare H2S levels and lung function in asthmatic children versus healthy controls.
Main Methods:
- Serum H2S levels and pulmonary function indices (FVC, FEV1, PEF, FEF25-75, MEF50, MEF25) were measured.
- Study included 64 children with asthma and 60 healthy children.
- Pearson's correlation analysis was employed to assess relationships.
Main Results:
- Children with asthma exhibited significantly lower serum H2S concentrations compared to healthy children.
- All measured lung function parameters were significantly reduced in children with asthma.
- Serum H2S concentration showed a significant positive correlation with lung function indices.
Conclusions:
- Decreased serum H2S levels in children may indicate diminished lung function.
- Serum H2S concentration could potentially serve as a biomarker for assessing lung function decline in pediatric asthma.
- Further research is warranted to elucidate the causal relationship between H2S and asthma pathophysiology.
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