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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...

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Related Experiment Video

Updated: May 22, 2026

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

Exercise and inflammation in pediatric Crohn's disease.

H Ploeger1, J Obeid, T Nguyen

  • 1Child Health & Exercise Medicine Program, McMaster University, Hamilton, Canada.

International Journal of Sports Medicine
|May 8, 2012
PubMed
Summary

Youth with Crohn's disease (CD) can safely exercise, as both moderate and high-intensity workouts did not worsen inflammation. Exercise responses in CD patients were similar to healthy individuals, showing no significant acute inflammatory exacerbation.

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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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Last Updated: May 22, 2026

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Area of Science:

  • Exercise physiology
  • Pediatric gastroenterology
  • Immunology

Background:

  • Crohn's disease (CD) is a chronic inflammatory condition affecting youth.
  • Exercise is often recommended for managing chronic diseases, but its impact on inflammation in pediatric CD requires further investigation.
  • Understanding exercise-induced immune responses is crucial for developing safe and effective physical activity guidelines for youth with CD.

Purpose of the Study:

  • To compare the acute inflammatory, immune cell, and growth factor responses to moderate-intensity continuous exercise (MICE) and high-intensity intermittent exercise (HIIE) in youth with CD and healthy controls.
  • To determine if different exercise intensities exacerbate inflammation in pediatric CD patients.
  • To assess the safety of distinct exercise modalities for youth with Crohn's disease.

Main Methods:

  • 15 youth with CD and 15 healthy controls underwent MICE (30 min cycling at 50% peak mechanical power) and HIIE (6 bouts of 15s cycling at 100% peak mechanical power).
  • Blood samples were collected at rest, mid-exercise, end-exercise, and 30 and 60 minutes into recovery.
  • Analyzed inflammatory cells (leukocytes, neutrophils, lymphocytes, monocytes), cytokines (IL-6, IL-17, TNF-α), and growth factors (GH, IGF-I).

Main Results:

  • Both MICE and HIIE increased immune cells and growth hormone (GH), and decreased insulin-like growth factor-I (IGF-I) in CD patients.
  • MICE induced a greater increase in leukocytes, neutrophils, lymphocytes, monocytes, IL-6, IL-17, and GH compared to HIIE.
  • Monocyte levels remained elevated longer in CD patients following MICE; TNF-α did not significantly change with either exercise type. Patient responses were largely similar to controls.

Conclusions:

  • Youth with Crohn's disease can participate in both moderate-intensity continuous exercise and high-intensity intermittent exercise without significant acute inflammatory exacerbation.
  • Exercise elicits comparable immune and growth factor responses in youth with CD and healthy controls.
  • Monocyte response duration differs between exercise types in CD patients, suggesting careful consideration of exercise prescription.