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Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

The preterm infant with thrombosis

Rukhmi Bhat1, Paul Monagle

  • 1Hematology/Oncology/Stem cell transplant, Children's Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA. rbhat@childrensmemorial.org

Archives of Disease in Childhood. Fetal and Neonatal Edition
|May 8, 2012
PubMed

Insights

Sick preterm infants face high risks of thrombosis due to factors like sepsis and genetic conditions. This review covers the causes, diagnosis, and treatment of blood clots in these vulnerable infants.

Area of Science:

  • Neonatal Medicine
  • Pediatric Hematology
  • Thrombosis Research

Background:

  • Preterm infants have unique hemostatic balance challenges.
  • Thrombotic complications are a significant risk in sick neonates.
  • Age-related coagulation differences exist in newborns.

Purpose of the Study:

  • To review the epidemiology of thrombosis in preterm infants.
  • To discuss the pathophysiology and risk factors for neonatal thrombosis.
  • To outline diagnostic and treatment strategies for thrombotic disorders.

Main Methods:

  • Literature review of pediatric thrombosis studies.
  • Analysis of risk factors including sepsis, asphyxia, and thrombophilia.
  • Examination of current anticoagulation practices extrapolated from adult data.

Main Results:

  • Sepsis, asphyxia, dehydration, central lines, and thrombophilia are key risk factors.
  • Anticoagulation is the primary treatment, often based on adult protocols.
  • Diagnosis and management require specialized neonatal expertise.

Conclusions:

  • Thrombosis is a critical concern in sick preterm infants.
  • Understanding risk factors is essential for prevention and early diagnosis.
  • Further research is needed for optimized, age-specific treatment guidelines.

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