Related Experiment Video

Updated: May 22, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

SIRT2 as a Therapeutic Target for Age-Related Disorders

Rita Machado de Oliveira1, Jana Sarkander, Aleksey G Kazantsev

  • 1Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular Lisboa, Portugal.

Frontiers in Pharmacology
|May 8, 2012
PubMed

Insights

Sirtuin 2 (SIRT2) protein regulates aging and age-related diseases like cancer and neurodegeneration. This review highlights SIRT2

Area of Science:

  • Biochemistry and Molecular Biology
  • Aging Research
  • Disease Pathogenesis

Background:

  • Sirtuins are key regulators of aging and age-related diseases, including cancer, diabetes, cardiovascular, and neurodegenerative disorders.
  • Mammalian sirtuins (SIRT1-7) exhibit diverse subcellular localizations and functions.
  • While SIRT1 is well-studied for its longevity effects, the roles of other sirtuins, including SIRT2, are increasingly recognized.

Purpose of the Study:

  • To review the biological functions of SIRT2 in cellular and tissue-specific contexts.
  • To explore the therapeutic potential of targeting SIRT2 for age-related diseases.

Main Methods:

  • Literature review of scientific advances on SIRT2 protein biology.
  • Analysis of studies investigating SIRT2's role in various physiological and pathological processes.

Main Results:

  • SIRT2 plays significant roles in cellular functions and tissue-specific processes.
  • Emerging evidence points to SIRT2's involvement in the pathogenesis of age-related diseases.
  • SIRT2's functions are distinct from the more extensively studied SIRT1.

Conclusions:

  • SIRT2 is a critical protein with underappreciated roles in aging and disease.
  • Targeting SIRT2 presents a promising therapeutic avenue for managing age-related disorders.
  • Further research into SIRT2 biology is warranted to fully exploit its therapeutic potential.
Keywords:
SIRT2agingcancermetabolic syndromeneurodegenerative disorder

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