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Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells
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Circulating CD62E+ microparticles and cardiovascular outcomes.

Soon-Tae Lee1, Kon Chu, Keun-Hwa Jung

  • 1Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.

Plos One
|May 8, 2012
PubMed
Summary
This summary is machine-generated.

High levels of CD62E(+) endothelial microparticles (EMPs) indicate increased cardiovascular event risk in stroke survivors. Other EMP types did not predict outcomes, highlighting CD62E(+) EMPs as a key biomarker.

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Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Endothelial Biology

Background:

  • Endothelial cells release microparticles (EMPs) expressing CD62E (E-selectin).
  • Systemic endothelial activation is implicated in cardiovascular disease.
  • Predictive biomarkers for cardiovascular events in stroke patients are needed.

Purpose of the Study:

  • To investigate if specific endothelial microparticle (EMP) levels predict cardiovascular outcomes in patients with a history of stroke.
  • To determine the prognostic value of CD62E(+), CD31(+)/Annexin-V(+), and CD31(+)/CD42(-) EMPs.

Main Methods:

  • Recruited 300 patients with stroke history.
  • Measured peripheral blood EMP levels using flow cytometry.
  • Monitored major cardiovascular events and death for 36 months.

Main Results:

  • Major cardiovascular events occurred in 9.7% of patients.
  • Higher CD62E(+) EMP levels correlated with lower event-free survival.
  • High CD62E(+) EMP levels predicted major cardiovascular events and hospitalization in multivariate analysis.
  • CD31(+)/Annexin-V(+) and CD31(+)/CD42(-) EMP levels were not predictive.

Conclusions:

  • Elevated CD62E(+) microparticle levels are associated with increased cardiovascular event risk in patients with a history of stroke.
  • Systemic endothelial activation, indicated by high CD62E(+) EMPs, may increase cardiovascular morbidity risk.
  • CD62E(+) EMPs show potential as a prognostic biomarker for cardiovascular events post-stroke.