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Updated: May 22, 2026
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Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
Published on: October 31, 2007
Single-center experience with pancreas transplantation.
1Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Transplantation Proceedings
|May 9, 2012
Summary
Pancreas transplantation (PT) offers improved patient and graft survival for diabetic patients. Recent advancements have significantly enhanced outcomes, making PT an effective treatment option.
Area of Science:
- Transplantation Medicine
- Endocrinology
- Surgical Outcomes
Background:
- Pancreas transplantation (PT) has seen recent improvements in patient and graft survival.
- Technical refinements, better immunosuppression, and postoperative management have reduced morbidity.
- This study analyzes 19 years of PT outcomes at a single center.
Purpose of the Study:
- To evaluate the long-term outcomes of pancreas transplantation.
- To assess patient and graft survival rates over a 19-year period.
- To identify factors influencing PT success.
Main Methods:
- A retrospective review of 153 pancreas transplant recipients (deceased or living donor) from July 1992 to July 2011.
- Analysis of operative records, clinical, and laboratory findings.
- Kaplan-Meier method used for graft and patient survival analysis.
Main Results:
- 153 pancreas transplants performed; 81.7% for type I diabetes, 18.3% for type II.
- Overall patient survival at 1, 5, and 10 years: 93.8%, 88.1%, 85.1%.
- Overall graft survival at 1, 5, and 10 years: 82.3%, 70.6%, 64.6%. Recent transplants (2006 onwards) showed significantly improved survival (P < .001).
Conclusions:
- Pancreas transplantation is an effective treatment for diabetic patients requiring insulin.
- Improved quality of life and long-term survival support PT as a viable option.
- PT outcomes are favorable regardless of diabetes type.
