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Related Experiment Video

Updated: May 22, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
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Can immune function assay predict infection or recovery?

H H Moon1, T-S Kim, Y-N Roh

  • 1Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Transplantation Proceedings
|May 9, 2012
PubMed
Summary
This summary is machine-generated.

The ImmuKnow assay can help monitor infectious syndromes in kidney transplant recipients. Longitudinal monitoring and value adjustment are key for detecting BK virus infections.

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Area of Science:

  • Transplantation immunology
  • Infectious disease monitoring
  • Biomarker analysis

Background:

  • The ImmuKnow assay is a global immune monitoring tool for organ transplant recipients.
  • This study investigated the predictive value of ImmuKnow ATP values for infectious syndromes in kidney transplant patients.

Purpose of the Study:

  • To assess if ImmuKnow assay values can predict infectious syndromes in kidney transplant recipients.
  • To evaluate the utility of ImmuKnow assay in monitoring BK virus infections.

Main Methods:

  • Prospective enrollment of 71 kidney transplant patients.
  • Serial ImmuKnow assay monitoring at multiple time points post-transplant.
  • Comparison of ImmuKnow values with BK viral infection status and clinical time points (pre-infection, detection, recovery).

Main Results:

  • Serial ImmuKnow assays showed significant differences over time and with BK viral infection status (P = .026).
  • Pre-infection (PI) values were lower than detection (DI) and pre-recovery (PR) values.
  • No absolute cutoff value was identified by ROC curve analysis, with 377 ng/mL showing 57.1% sensitivity and 56.2% specificity.

Conclusions:

  • Longitudinal evaluation and adjustment of ImmuKnow assay values are favorable for monitoring infectious syndromes.
  • The ImmuKnow assay appears particularly useful for monitoring BK virus infections post-transplantation.