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Lichen planus induced by carbamazepine: a case report
S Hajnsek1, V Milavec-Puretic, S Nankovic
1University Hospital Center Zagreb, Zagreb, Croatia. centar-za-epilepsiju@net.hr
Epilepsy & Behavior : E&B
|May 9, 2012
Summary
A patient treated for epilepsy with carbamazepine developed Lichen planus. Switching to oxcarbazepine and using steroid therapy successfully resolved the skin condition.
Area of Science:
- Dermatology
- Neurology
- Pharmacology
Background:
- Epilepsy management often involves long-term anticonvulsant medication.
- Carbamazepine is a commonly prescribed antiepileptic drug.
- Drug-induced skin reactions are a known concern in pharmacotherapy.
Observation:
- A female patient with mesio-temporal lobe epilepsy on carbamazepine developed an itchy, widespread rash.
- The rash presented as erythematous papulosquamous lesions on the trunk, breasts, and legs.
- Dermatohistological examination confirmed the diagnosis of Lichen planus.
Findings:
- The patient's Lichen planus was likely a side effect of carbamazepine treatment.
- Discontinuation of carbamazepine and initiation of oxcarbazepine led to symptom improvement.
- Adjunctive topical steroid therapy further aided in the regression of skin changes.
Implications:
- This case highlights the importance of considering drug-induced dermatoses in patients on antiepileptic drugs.
- It suggests that oxcarbazepine may be a viable alternative for epilepsy patients experiencing carbamazepine-related skin reactions.
- Monitoring for cutaneous adverse events is crucial for patients undergoing long-term anticonvulsant therapy.
