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Related Concept Videos

Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is formed in...
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Microbial Leaching01:27

Microbial Leaching

Microbial leaching, also known as bioleaching, is an environmentally favorable method for extracting metals from low-grade ores using specific microorganisms. This biotechnological approach is particularly valuable for mining operations targeting copper, gold, and uranium, where traditional extraction methods may be economically or environmentally impractical.Copper Leaching and Microbial CatalysisIn copper bioleaching, crushed ore is arranged into heaps and irrigated with a dilute sulfuric...
Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...

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Related Experiment Video

Updated: May 22, 2026

Quantifiable and Inexpensive Cell-Free Fluorescent Method to Confirm the Ability of Novel Compounds to Chelate Iron
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Quantifiable and Inexpensive Cell-Free Fluorescent Method to Confirm the Ability of Novel Compounds to Chelate Iron

Published on: February 23, 2024

Iron mobilization using chelation and phlebotomy.

Trond Peder Flaten1, Jan Aaseth, Ole Andersen

  • 1Department of Chemistry, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway. trond.flaten@chem.ntnu.no

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|May 9, 2012
PubMed
Summary
This summary is machine-generated.

Iron overload affects millions globally. New oral iron chelators like deferiprone and deferasirox offer improved treatment options alongside traditional methods such as phlebotomy and chelation therapy.

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Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))
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Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))

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Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))
04:48

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))

Published on: May 4, 2020

Area of Science:

  • Hematology
  • Pharmacology
  • Public Health

Background:

  • Iron metabolism knowledge has advanced, aiding management of iron deficiency and overload.
  • Iron overload, with genetic and environmental causes, affects millions worldwide, causing severe health issues.
  • Hereditary hemochromatosis and transfusional siderosis (in thalassemia, etc.) are common iron overload disorders.

Purpose of the Study:

  • To review advancements in understanding and treating iron overload disorders.
  • To highlight the need for and development of effective oral iron chelators.
  • To discuss the efficacy of existing and novel iron chelation therapies.

Main Methods:

  • Review of current knowledge on iron metabolism and overload mechanisms.
  • Analysis of established treatments: phlebotomy and chelation therapy (deferoxamine).
  • Evaluation of newly approved oral iron chelators: deferiprone and deferasirox.

Main Results:

  • Phlebotomy is primary for hereditary hemochromatosis; chelation is key for transfusional siderosis.
  • Deferoxamine's limitations (poor oral absorption) necessitate alternative treatments.
  • Deferiprone and deferasirox show promise as effective oral iron chelators.

Conclusions:

  • Significant progress in iron metabolism knowledge improves management of iron overload.
  • Oral iron chelators represent a major advancement, enhancing patient compliance and treatment effectiveness.
  • Combined chelation therapies, such as subcutaneous deferoxamine with oral deferiprone, show particular promise.