Should we screen children with severe acute malnutrition for celiac disease?
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Updated: May 22, 2026

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Published on: July 5, 2022
Insights
Severe acute malnutrition (SAM) in children can mimic celiac disease symptoms. This study found celiac disease in 13.1% of SAM cases, highlighting the need for its investigation.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
Background:
- Clinical presentation of severe acute malnutrition (SAM) often overlaps with other conditions.
- Investigating co-existing diseases in SAM children is crucial for effective management.
Discussion:
- This pilot study explored the prevalence of celiac disease, tuberculosis (TB), and human immunodeficiency virus (HIV) in children with SAM.
- The overlap in clinical features necessitates differential diagnosis.
Key Insights:
- Celiac disease was diagnosed in 13.1% of children with SAM.
- Tuberculosis and HIV were found in 9.3% and 4% of SAM children, respectively.
- These findings underscore the importance of screening for these conditions in SAM patients.
Outlook:
- Further research with larger cohorts is needed to confirm these prevalence rates.
- Implementing routine screening protocols for celiac disease, TB, and HIV in SAM populations could improve patient outcomes.
Abstract:
The clinical features of severe acute malnutrition (SAM) often overlap with the common manifestations of celiac disease. In this observational pilot study, 76 children fulfilling the case definition of SAM were investigated for celiac disease, tuberculosis and HIV. Celiac disease was diagnosed in 13.1% of SAM children while tuberculosis and HIV were diagnosed in 9.3% and 4%, respectively.
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