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Updated: May 22, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
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Published on: November 24, 2020

Triglycerides: a case for treatment?

Anthony S Wierzbicki1, Rosemary E Clarke, Adie Viljoen

  • 1Guy's and St Thomas' Hospitals, London, Lambeth, UK. Anthony.Wierzbicki@kcl.ac.uk

Current Opinion in Cardiology
|May 9, 2012
PubMed
Summary
This summary is machine-generated.

High triglycerides significantly increase cardiovascular disease (CVD) risk, even with statin therapy. Further research on non-statin lipid-lowering agents is needed for patients with controlled LDL cholesterol.

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Last Updated: May 22, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Lipidology

Background:

  • Triglycerides are a key component of lipid profiles and metabolic syndrome.
  • Elevated triglycerides are linked to increased risk of diabetes and cardiovascular disease (CVD).

Purpose of the Study:

  • To review the significance of triglycerides in cardiovascular disease (CVD) risk.
  • To evaluate the efficacy of lipid-lowering agents beyond statins.

Main Methods:

  • Review of existing clinical trials and evidence regarding triglyceride levels and CVD.
  • Analysis of studies on niacin, fibrates, and omega-3 fatty acids for triglyceride management.

Main Results:

  • Triglyceride-rich particles contribute to CVD risk independently of LDL cholesterol.
  • While older monotherapy trials showed some benefit, adding niacin or fenofibrate to statins yielded no significant CVD event reduction, except possibly in specific patient subgroups.
  • Omega-3 fatty acid trials showed CVD event reduction but often used insufficient doses or studied patients with inadequately controlled LDL-C.

Conclusions:

  • Further clinical trials are necessary to identify effective lipid-lowering strategies beyond statins for patients with well-controlled LDL cholesterol.
  • The role of triglyceride-lowering agents in residual CVD risk management requires further investigation.